Association between the rs1052133 polymorphism of the OGG1 gene and the risk of malignant neoplasms development in people chronically exposed to radiation

Genetic predisposition without doubt is one of the risk factors cancer initiation. It known that single nucleotide polymorphisms (SNP) genes maintain genome stability, including SNP DNA repair, may contribute to initiation carcinogenesis. Single-nucleotide support repair genes, can Polymorphism excision gene OGG1 causes interest leading scientific groups from various countries. assumed there relationship between rs1052133 polymorphism in and The objective this study was establish association base people chronically exposed ionizing radiation. Residents (888 people) Techa riverside settlements, low or medium radiation River East-Urals Radioactive Trace were included study. allowed researchers chronic people, carriers rs1052133*G allele have increased malignant neoplasms initiation: OR=1.38; 95% CI [1.05-1.83], p=0.023. multifactorial synergistic interactions dose red bone marrow found: Testing Balanced Accuracy (TBA)=0.56; Cross Validation Consistency (CVC)=10/10; p=0.01). found be considered as genetical marker with doses ranged 0.74 3507.07 mGy (average 523.10+/-33.89 mGy). presence combination exposure modify solid cancers initiation, it indicated by dose.